CA12
Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| carbonic anhydrase 12 | MIM:603263 | Ensembl:ENSG00000074410 | HGNC:HGNC:1371 | PA25987 | 15q22.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CA12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004089 | carbonate dehydratase activity |
| MF | IEA | GO:0008270 | zinc ion binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | TAS | GO:0015701 | bicarbonate transport |
| BP | IMP | GO:0055064 | chloride ion homeostasis |
Gene expression in normal tissue: CA12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CA12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1475029 | Reversible hydration of carbon dioxide |
| kegg | hsa00910 | Nitrogen metabolism - Homo sapiens (human) |
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CA12
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