CA9


Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
carbonic anhydrase 9MIM:603179Ensembl:ENSG00000107159HGNC:HGNC:1383PA259989p13.3

GO terms in CA9


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004089carbonate dehydratase activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
CCIEAGO:0005730nucleolus
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0016323basolateral plasma membrane
CCIEAGO:0031528microvillus membrane
BPIEAGO:0002009morphogenesis of an epithelium
BPTASGO:0015701bicarbonate transport
BPIEAGO:0033574response to testosterone
BPIEAGO:0042493response to drug
BPIEAGO:0046903secretion
BPTASGO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia

Gene expression in normal tissue: CA9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CA9


DatabasePathway IDPathway Des.
pidhif1_tfpathwayHIF-1-alpha transcription factor network
kegghsa00910Nitrogen metabolism - Homo sapiens (human)
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
wikipathwaysWP2727Regulation of Hypoxia-inducible Factor (HIF) by oxygen
wikipathwaysWP2877Vitamin D Receptor Pathway
reactomeR-HSA-1234158Regulation of gene expression by Hypoxia-inducible Factor
reactomeR-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1475029Reversible hydration of carbon dioxide
reactomeR-HSA-2262749Cellular response to hypoxia
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-8953897Cellular responses to external stimuli

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD241Sunitinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CA9

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