CAPN2


Summary: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
calpain 2MIM:114230Ensembl:ENSG00000162909HGNC:HGNC:1479PA260601q41

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in CAPN2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001666response to hypoxia
BPIEAGO:0001824blastocyst development
BPIBAGO:0006508proteolysis
BPISSGO:0006508proteolysis
BPIEAGO:0007520myoblast fusion
BPIEAGO:0016540protein autoprocessing
BPTASGO:0051493regulation of cytoskeleton organization
BPIDAGO:0051603proteolysis involved in cellular protein catabolic process
BPISSGO:0071230cellular response to amino acid stimulus
CCIEAGO:0000785chromatin
CCIEAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCIEAGO:0005764lysosome
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCISSGO:0030425dendrite
CCTASGO:0030864cortical actin cytoskeleton
CCIDAGO:0031143pseudopodium
CCIDAGO:0045121membrane raft
CCIDAGO:0045121membrane raft
CCHDAGO:0070062extracellular exosome
CCIDAGO:0097038perinuclear endoplasmic reticulum
MFIBAGO:0004198calcium-dependent cysteine-type endopeptidase activity
MFIDAGO:0004198calcium-dependent cysteine-type endopeptidase activity
MFISSGO:0004198calcium-dependent cysteine-type endopeptidase activity
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFNASGO:0008092cytoskeletal protein binding
MFTASGO:0008234cysteine-type peptidase activity
MFIEAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: CAPN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CAPN2


DatabasePathway IDPathway Des.
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643685Disease
reactomeR-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
reactomeR-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
reactomeR-HSA-8863678Neurodegenerative Diseases
reactomeR-HSA-8863678Neurodegenerative Diseases
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartamef2dpathwayrole of mef2d in t-cell apoptosis
piderbb1_downstream_pathwayErbB1 downstream signaling
pidfak_pathwaySignaling events mediated by focal adhesion kinase
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAPN2

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