CARNMT1
Summary: The protein encoded by this gene is a methyltransferase that converts carnosine to anserine, a dipeptide found abundantly in skeletal muscle. The encoded protein can methylate other dipeptides as well. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
carnosine N-methyltransferase 1 | MIM:616552 | Ensembl:ENSG00000156017 | HGNC:HGNC:23435 | PA134929393 | 9q21.13 |
GO terms in CARNMT1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity |
MF | IBA | GO:0030735 | carnosine N-methyltransferase activity |
MF | IDA | GO:0030735 | carnosine N-methyltransferase activity |
MF | TAS | GO:0030735 | carnosine N-methyltransferase activity |
CC | IBA | GO:0005634 | nucleus |
CC | IDA | GO:0005634 | nucleus |
CC | IBA | GO:0005829 | cytosol |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
BP | TAS | GO:0006548 | histidine catabolic process |
BP | IEA | GO:0032259 | methylation |
BP | IBA | GO:0035498 | carnosine metabolic process |
BP | IDA | GO:0035498 | carnosine metabolic process |
Gene expression in normal tissue: CARNMT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CARNMT1
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa00340 | Histidine metabolism - Homo sapiens (human) |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-6788656 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism |
reactome | R-HSA-70921 | Histidine catabolism |
reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CARNMT1