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CARNMT1

Summary: The protein encoded by this gene is a methyltransferase that converts carnosine to anserine, a dipeptide found abundantly in skeletal muscle. The encoded protein can methylate other dipeptides as well. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
carnosine N-methyltransferase 1	MIM:616552	Ensembl:ENSG00000156017	HGNC:HGNC:23435	PA134929393	9q21.13

GO terms in CARNMT1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
MF	IBA	GO:0030735	carnosine N-methyltransferase activity
MF	IDA	GO:0030735	carnosine N-methyltransferase activity
MF	TAS	GO:0030735	carnosine N-methyltransferase activity
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IBA	GO:0005829	cytosol
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
BP	TAS	GO:0006548	histidine catabolic process
BP	IEA	GO:0032259	methylation
BP	IBA	GO:0035498	carnosine metabolic process
BP	IDA	GO:0035498	carnosine metabolic process

Gene expression in normal tissue: CARNMT1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CARNMT1

Database	Pathway ID	Pathway Des.
kegg	hsa00340	Histidine metabolism - Homo sapiens (human)
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
reactome	R-HSA-70921	Histidine catabolism
reactome	R-HSA-71291	Metabolism of amino acids and derivatives

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CARNMT1

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