CARS2


Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cysteinyl-tRNA synthetase 2, mitochondrialMIM:612800Ensembl:ENSG00000134905HGNC:HGNC:25695PA16238108313q34

GO terms in CARS2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004817cysteine-tRNA ligase activity
MFIBAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding
BPIBAGO:0006423cysteinyl-tRNA aminoacylation
CCIBAGO:0005737cytoplasm
CCIEAGO:0005759mitochondrial matrix

Gene expression in normal tissue: CARS2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CARS2


DatabasePathway IDPathway Des.
reactomeR-HSA-379724tRNA Aminoacylation
reactomeR-HSA-379726Mitochondrial tRNA aminoacylation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-72766Translation
humancycTRNA-CHARGING-PWYtRNA charging
kegghsa00970Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CARS2

​​​​