Summary: This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013].

coiled-coil domain containing 88CMIM:611204Ensembl:ENSG00000015133HGNC:HGNC:19967PA16238187914q32.11-q32.12

GO terms in CCDC88C

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0008017microtubule binding
MFISSGO:0030165PDZ domain binding
MFISSGO:0043621protein self-association
MFIBAGO:0051959dynein light intermediate chain binding
BPISSGO:0001932regulation of protein phosphorylation
BPIEAGO:0016055Wnt signaling pathway
BPIBAGO:0030705cytoskeleton-dependent intracellular transport
BPIMPGO:0031098stress-activated protein kinase signaling cascade
BPIBAGO:0031122cytoplasmic microtubule organization
BPISSGO:0031648protein destabilization
BPISSGO:0051260protein homooligomerization

Gene expression in normal tissue: CCDC88C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCDC88C

DatabasePathway IDPathway Des.
wikipathwaysWP2858Ectoderm Differentiation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-5368598Negative regulation of TCF-dependent signaling by DVL-interacting proteins

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCDC88C