CCKBR
Summary: This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cholecystokinin B receptor | MIM:118445 | Ensembl:ENSG00000110148 | HGNC:HGNC:1571 | PA26143 | 11p15.4 |
GO terms in CCKBR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001696 | gastric acid secretion |
| BP | NAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0038188 | cholecystokinin signaling pathway |
| BP | IEA | GO:0043551 | regulation of phosphatidylinositol 3-kinase activity |
| BP | IEA | GO:0048565 | digestive tract development |
| BP | IEA | GO:0048732 | gland development |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | IDA | GO:0004951 | cholecystokinin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0015054 | gastrin receptor activity |
| MF | IPI | GO:0017046 | peptide hormone binding |
| MF | IDA | GO:0031741 | type B gastrin/cholecystokinin receptor binding |
| MF | TAS | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity |
Gene expression in normal tissue: CCKBR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCKBR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00225 | Esomeprazole Action Pathway |
| smpdb | SMP00226 | Omeprazole Action Pathway |
| smpdb | SMP00227 | Lansoprazole Action Pathway |
| smpdb | SMP00228 | Pantoprazole Action Pathway |
| smpdb | SMP00229 | Rabeprazole Action Pathway |
| smpdb | SMP00230 | Ranitidine Action Pathway |
| smpdb | SMP00231 | Famotidine Action Pathway |
| smpdb | SMP00232 | Cimetidine Action Pathway |
| smpdb | SMP00233 | Nizatidine Action Pathway |
| smpdb | SMP00246 | Pirenzepine Action Pathway |
| smpdb | SMP00589 | Gastric Acid Production |
| smpdb | SMP00734 | Roxatidine acetate Action Pathway |
| smpdb | SMP00735 | Metiamide Action Pathway |
| smpdb | SMP00736 | Betazole Action Pathway |
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP2597 | Secretion of Hydrochloric Acid in Parietal Cells |
| wikipathways | WP3679 | Cell-type Dependent Selectivity of CCK2R Signaling |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| netpath | Pathway_Gastrin | Gastrin |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCKBR
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