Summary: Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008].

cyclin B2MIM:602755Ensembl:ENSG00000157456HGNC:HGNC:1580PA2614815q22.2

GO terms in CCNB2

Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000307cyclin-dependent protein kinase holoenzyme complex
CCIDAGO:0015630microtubule cytoskeleton
BPIBAGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPIBAGO:0000278mitotic cell cycle
BPIEAGO:0001701in utero embryonic development
BPTASGO:0007077mitotic nuclear envelope disassembly
BPIBAGO:0007088regulation of mitotic nuclear division
BPIBAGO:0008284positive regulation of cell proliferation
BPIEAGO:0043029T cell homeostasis
BPIBAGO:0045787positive regulation of cell cycle
BPIEAGO:0048538thymus development
BPIEAGO:0051301cell division
BPTASGO:0051726regulation of cell cycle
MFIBAGO:0004672protein kinase activity
MFTASGO:0004693cyclin-dependent protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIBAGO:0016538cyclin-dependent protein serine/threonine kinase regulator activity
MFIBAGO:0019901protein kinase binding
MFHDAGO:0045296cadherin binding

Gene expression in normal tissue: CCNB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCNB2

DatabasePathway IDPathway Des.
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP179Cell Cycle
wikipathwaysWP1859Mitotic G2-G2-M phases
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP707DNA Damage Response
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
pidfoxm1pathwayFOXM1 transcription factor network
biocartaefppathwayestrogen responsive protein efp controls cell cycle and breast tumors growth
reactomeR-HSA-156711Polo-like kinase mediated events
reactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack Reorganization
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-2500257Resolution of Sister Chromatid Cohesion
reactomeR-HSA-2514853Condensation of Prometaphase Chromosomes
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-2980766Nuclear Envelope Breakdown
reactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7
reactomeR-HSA-3301854Nuclear Pore Complex (NPC) Disassembly
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69478G2/M DNA replication checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpoint

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCNB2