CCNH
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin H | MIM:601953 | Ensembl:ENSG00000134480 | HGNC:HGNC:1594 | PA26159 | 5q14.3 |
GO terms in CCNH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008094 | DNA-dependent ATPase activity |
| MF | IDA | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity |
| MF | IBA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005675 | holo TFIIH complex |
| CC | IDA | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex |
| CC | IMP | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex |
| CC | IEA | GO:0070985 | TFIIK complex |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | TAS | GO:0006294 | nucleotide-excision repair, preincision complex assembly |
| BP | TAS | GO:0006361 | transcription initiation from RNA polymerase I promoter |
| BP | TAS | GO:0006363 | termination of RNA polymerase I transcription |
| BP | IDA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | TAS | GO:0006370 | 7-methylguanosine mRNA capping |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IBA | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain |
Gene expression in normal tissue: CCNH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCNH
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112382 | Formation of RNA Pol II elongation complex |
| reactome | R-HSA-113418 | Formation of the Early Elongation Complex |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat |
| reactome | R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex |
| reactome | R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| reactome | R-HSA-167161 | HIV Transcription Initiation |
| reactome | R-HSA-167162 | RNA Polymerase II HIV Promoter Escape |
| reactome | R-HSA-167169 | HIV Transcription Elongation |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| reactome | R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5696395 | Formation of Incision Complex in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6782135 | Dual incision in TC-NER |
| reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-72086 | mRNA Capping |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73772 | RNA Polymerase I Promoter Escape |
| reactome | R-HSA-73776 | RNA Polymerase II Promoter Escape |
| reactome | R-HSA-73777 | RNA Polymerase I Chain Elongation |
| reactome | R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73863 | RNA Polymerase I Transcription Termination |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75953 | RNA Polymerase II Transcription Initiation |
| reactome | R-HSA-75955 | RNA Polymerase II Transcription Elongation |
| reactome | R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| reactome | R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | ptc1pathway | sonic hedgehog receptor ptc1 regulates cell cycle |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| kegg | hsa03022 | Basal transcription factors - Homo sapiens (human) |
| kegg | hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP405 | Eukaryotic Transcription Initiation |
| wikipathways | WP45 | G1 to S cell cycle control |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCNH
CLASSFICATION
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