CD151


Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CD151 molecule (Raph blood group)MIM:602243Ensembl:ENSG00000177697HGNC:HGNC:1630PA2618911p15.5

Gene Categories:

DRUGGABLE GENOME

GO terms in CD151


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005178integrin binding
MFIPIGO:0005178integrin binding
MFIPIGO:0005515protein binding
BPNASGO:0007155cell adhesion
BPIBAGO:0007166cell surface receptor signaling pathway
BPIDAGO:0030335positive regulation of cell migration
BPIMPGO:0030335positive regulation of cell migration
BPTASGO:0031581hemidesmosome assembly
BPIEAGO:0042098T cell proliferation
BPIDAGO:0044319wound healing, spreading of cells
BPIMPGO:0044319wound healing, spreading of cells
BPIDAGO:0045807positive regulation of endocytosis
BPIMPGO:0045807positive regulation of endocytosis
CCIDAGO:0005604basement membrane
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCIDAGO:0009986cell surface
CCTASGO:0016020membrane

Gene expression in normal tissue: CD151

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD151


DatabasePathway IDPathway Des.
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474290Collagen formation
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-2022090Assembly of collagen fibrils and other multimeric structures
reactomeR-HSA-446107Type I hemidesmosome assembly
reactomeR-HSA-446728Cell junction organization
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD151

​​​​