CD247
Summary: The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
CD247 molecule | MIM:186780 | Ensembl:ENSG00000198821 | HGNC:HGNC:1677 | PA26219 | 1q24.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CD247
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | IEA | GO:0016021 | integral component of membrane |
CC | IBA | GO:0042101 | T cell receptor complex |
CC | IDA | GO:0042101 | T cell receptor complex |
CC | IEA | GO:0042105 | alpha-beta T cell receptor complex |
BP | IEA | GO:0002250 | adaptive immune response |
BP | IEA | GO:0032623 | interleukin-2 production |
BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
BP | TAS | GO:0050690 | regulation of defense response to virus by virus |
BP | TAS | GO:0050776 | regulation of immune response |
BP | TAS | GO:0050852 | T cell receptor signaling pathway |
BP | IMP | GO:0051289 | protein homotetramerization |
BP | IMP | GO:0070207 | protein homotrimerization |
BP | IEA | GO:2000010 | positive regulation of protein localization to cell surface |
MF | IEA | GO:0004888 | transmembrane signaling receptor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0042802 | identical protein binding |
MF | IMP | GO:0042803 | protein homodimerization activity |
MF | NAS | GO:0042803 | protein homodimerization activity |
MF | IPI | GO:1990782 | protein tyrosine kinase binding |
Gene expression in normal tissue: CD247
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD247
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
netpath | Pathway_TCR | TCR |
pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
pid | cxcr4_pathway | CXCR4-mediated signaling events |
pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
pid | il12_2pathway | IL12-mediated signaling events |
pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
biocarta | tcrapathway | lck and fyn tyrosine kinases in initiation of tcr activation |
biocarta | tcrpathway | t cell receptor signaling pathway |
reactome | R-HSA-1280218 | Adaptive Immune System |
reactome | R-HSA-162906 | HIV Infection |
reactome | R-HSA-162909 | Host Interactions of HIV factors |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-164944 | Nef and signal transduction |
reactome | R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis |
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
reactome | R-HSA-202403 | TCR signaling |
reactome | R-HSA-202424 | Downstream TCR signaling |
reactome | R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains |
reactome | R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse |
reactome | R-HSA-202433 | Generation of second messenger molecules |
reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
reactome | R-HSA-2029481 | FCGR activation |
reactome | R-HSA-2029481 | FCGR activation |
reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
reactome | R-HSA-388841 | Costimulation by the CD28 family |
reactome | R-HSA-389948 | PD-1 signaling |
reactome | R-HSA-5663205 | Infectious disease |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD247