CD247


Summary: The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CD247 moleculeMIM:186780Ensembl:ENSG00000198821HGNC:HGNC:1677PA262191q24.2

Gene Categories:

DRUGGABLE GENOME

GO terms in CD247


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0042101T cell receptor complex
CCIDAGO:0042101T cell receptor complex
CCIEAGO:0042105alpha-beta T cell receptor complex
BPIEAGO:0002250adaptive immune response
BPIEAGO:0032623interleukin-2 production
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPTASGO:0050690regulation of defense response to virus by virus
BPTASGO:0050776regulation of immune response
BPTASGO:0050852T cell receptor signaling pathway
BPIMPGO:0051289protein homotetramerization
BPIMPGO:0070207protein homotrimerization
BPIEAGO:2000010positive regulation of protein localization to cell surface
MFIEAGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIMPGO:0042803protein homodimerization activity
MFNASGO:0042803protein homodimerization activity
MFIPIGO:1990782protein tyrosine kinase binding

Gene expression in normal tissue: CD247

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD247


DatabasePathway IDPathway Des.
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
netpathPathway_TCRTCR
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidcxcr4_pathwayCXCR4-mediated signaling events
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidil12_2pathwayIL12-mediated signaling events
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartactla4pathwaythe co-stimulatory signal during t-cell activation
biocartamef2dpathwayrole of mef2d in t-cell apoptosis
biocartastathminpathwaystathmin and breast cancer resistance to antimicrotubule agents
biocartatcrapathwaylck and fyn tyrosine kinases in initiation of tcr activation
biocartatcrpathwayt cell receptor signaling pathway
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-1643685Disease
reactomeR-HSA-164944Nef and signal transduction
reactomeR-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesis
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-202427Phosphorylation of CD3 and TCR zeta chains
reactomeR-HSA-202430Translocation of ZAP-70 to Immunological synapse
reactomeR-HSA-202433Generation of second messenger molecules
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029481FCGR activation
reactomeR-HSA-2029481FCGR activation
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-2029485Role of phospholipids in phagocytosis
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389948PD-1 signaling
reactomeR-HSA-5663205Infectious disease

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD247

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