CD68


Summary: This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:153634
PHARMGKB IDPA26232
Map Location17p13.1

Gene Categories:

DRUGGABLE GENOME

GO terms in CD68


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IEA GO:0010008 endosome membrane
CC TAS GO:0016020 membrane
CC IEA GO:0016021 integral component of membrane
CC TAS GO:0035577 azurophil granule membrane
BP TAS GO:0043312 neutrophil degranulation
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Gene expression in normal tissue: CD68

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD68


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Database
Pathway ID
Pathway Des.
kegg hsa04142 Lysosome - Homo sapiens (human)
wikipathways WP3936 Macrophage markers
wikipathways WP4146 Macrophage markers
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-6798695 Neutrophil degranulation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD68

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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