CDH8
Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cadherin 8 | MIM:603008 | Ensembl:ENSG00000150394 | HGNC:HGNC:1767 | PA26304 | 16q21 |
GO terms in CDH8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000902 | cell morphogenesis |
| BP | IBA | GO:0007043 | cell-cell junction assembly |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0009409 | response to cold |
| BP | IBA | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IBA | GO:0034332 | adherens junction organization |
| BP | TAS | GO:0034332 | adherens junction organization |
| BP | IBA | GO:0035249 | synaptic transmission, glutamatergic |
| BP | IEA | GO:0035249 | synaptic transmission, glutamatergic |
| BP | IBA | GO:0044331 | cell-cell adhesion mediated by cadherin |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005913 | cell-cell adherens junction |
| CC | IBA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0016342 | catenin complex |
| CC | IBA | GO:0043083 | synaptic cleft |
| CC | IEA | GO:0043083 | synaptic cleft |
| CC | IBA | GO:0043679 | axon terminus |
| CC | IEA | GO:0043679 | axon terminus |
| MF | IBA | GO:0005509 | calcium ion binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IBA | GO:0008092 | cytoskeletal protein binding |
| MF | IEA | GO:0042802 | identical protein binding |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: CDH8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDH8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2858 | Ectoderm Differentiation |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-418990 | Adherens junctions interactions |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDH8
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