CELF1


Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CUGBP Elav-like family member 1MIM:601074Ensembl:ENSG00000149187HGNC:HGNC:2549PA2704511p11.2

GO terms in CELF1


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0000900translation repressor activity, mRNA regulatory element binding
MFHDAGO:0003723RNA binding
MFIBAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFIBAGO:0003729mRNA binding
MFIDAGO:0003729mRNA binding
MFIPIGO:0005515protein binding
MFIDAGO:0036002pre-mRNA binding
MFIDAGO:0042835BRE binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIEAGO:0005737cytoplasm
CCHDAGO:0016020membrane
CCNASGO:1990904ribonucleoprotein complex
BPIBAGO:0000381regulation of alternative mRNA splicing, via spliceosome
BPIBAGO:0006376mRNA splice site selection
BPIDAGO:0006376mRNA splice site selection
BPISSGO:0006376mRNA splice site selection
BPTASGO:0006397mRNA processing
BPNASGO:0007281germ cell development
BPNASGO:0009792embryo development ending in birth or egg hatching
BPNASGO:0016246RNA interference
BPIEAGO:0017148negative regulation of translation
BPIDAGO:0043484regulation of RNA splicing

Gene expression in normal tissue: CELF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CELF1


DatabasePathway IDPathway Des.
wikipathwaysWP236Adipogenesis
wikipathwaysWP411mRNA Processing

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CELF1

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