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CEMIP2

Summary: This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
cell migration inducing hyaluronidase 2	MIM:605835	Ensembl:ENSG00000135048	HGNC:HGNC:11869	PA36570	9q21.13

GO terms in CEMIP2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004415	hyalurononglucosaminidase activity
MF	IDA	GO:0005509	calcium ion binding
MF	HDA	GO:0045296	cadherin binding
BP	IEA	GO:0001525	angiogenesis
BP	IDA	GO:0030214	hyaluronan catabolic process
BP	ISS	GO:1903670	regulation of sprouting angiogenesis
CC	IDA	GO:0005887	integral component of plasma membrane
CC	TAS	GO:0016021	integral component of membrane
CC	HDA	GO:0070062	extracellular exosome

Gene expression in normal tissue: CEMIP2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CEMIP2

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CEMIP2

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