CENPS


Summary: This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
centromere protein SMIM:609130Ensembl:ENSG00000175279HGNC:HGNC:23163PA1348616141p36.22

Gene Categories:

DNA REPAIR

GO terms in CENPS


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003677DNA binding
MFIBAGO:0003682chromatin binding
MFIDAGO:0003682chromatin binding
MFIBAGO:0003690double-stranded DNA binding
MFIDAGO:0003690double-stranded DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0046982protein heterodimerization activity
BPIBAGO:0000712resolution of meiotic recombination intermediates
BPIMPGO:0000712resolution of meiotic recombination intermediates
BPIDAGO:0006281DNA repair
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIBAGO:0031297replication fork processing
BPIMPGO:0031297replication fork processing
BPTASGO:0031398positive regulation of protein ubiquitination
BPTASGO:0034080CENP-A containing nucleosome assembly
BPTASGO:0036297interstrand cross-link repair
BPIEAGO:0051301cell division
BPIEAGO:0051382kinetochore assembly
CCIEAGO:0000777condensed chromosome kinetochore
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIBAGO:0043240Fanconi anaemia nuclear complex
CCIDAGO:0043240Fanconi anaemia nuclear complex
CCIBAGO:0071821FANCM-MHF complex
CCIDAGO:0071821FANCM-MHF complex

Gene expression in normal tissue: CENPS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CENPS


DatabasePathway IDPathway Des.
reactomeR-HSA-141424Amplification of signal from the kinetochores
reactomeR-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2467813Separation of Sister Chromatids
reactomeR-HSA-2500257Resolution of Sister Chromatid Cohesion
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-5663220RHO GTPases Activate Formins
reactomeR-HSA-606279Deposition of new CENPA-containing nucleosomes at the centromere
reactomeR-HSA-6783310Fanconi Anemia Pathway
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68882Mitotic Anaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69618Mitotic Spindle Checkpoint
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73886Chromosome Maintenance
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-774815Nucleosome assembly
kegghsa03460Fanconi anemia pathway - Homo sapiens (human)
pidfanconi_pathwayFanconi anemia pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CENPS

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