CENPS
Summary: This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| centromere protein S | MIM:609130 | Ensembl:ENSG00000175279 | HGNC:HGNC:23163 | PA134861614 | 1p36.22 |
Gene Categories:
DNA REPAIRGO terms in CENPS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003690 | double-stranded DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| BP | IBA | GO:0000712 | resolution of meiotic recombination intermediates |
| BP | IMP | GO:0000712 | resolution of meiotic recombination intermediates |
| BP | IDA | GO:0006281 | DNA repair |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IBA | GO:0031297 | replication fork processing |
| BP | IMP | GO:0031297 | replication fork processing |
| BP | TAS | GO:0031398 | positive regulation of protein ubiquitination |
| BP | TAS | GO:0034080 | CENP-A containing nucleosome assembly |
| BP | TAS | GO:0036297 | interstrand cross-link repair |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051382 | kinetochore assembly |
| CC | IEA | GO:0000777 | condensed chromosome kinetochore |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0043240 | Fanconi anaemia nuclear complex |
| CC | IDA | GO:0043240 | Fanconi anaemia nuclear complex |
| CC | IBA | GO:0071821 | FANCM-MHF complex |
| CC | IDA | GO:0071821 | FANCM-MHF complex |
Gene expression in normal tissue: CENPS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CENPS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere |
| reactome | R-HSA-6783310 | Fanconi Anemia Pathway |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-774815 | Nucleosome assembly |
| kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
| pid | fanconi_pathway | Fanconi anemia pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CENPS
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