Summary: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010].

carboxylesterase 3MIM:605279Ensembl:ENSG00000172828HGNC:HGNC:1865PA2641816q22.1

Gene Categories:


GO terms in CES3

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004771sterol esterase activity
MFIBAGO:0004806triglyceride lipase activity
MFIBAGO:0052689carboxylic ester hydrolase activity
MFTASGO:0052689carboxylic ester hydrolase activity
CCIBAGO:0005615extracellular space
CCIEAGO:0005788endoplasmic reticulum lumen
CCHDAGO:0070062extracellular exosome
BPTASGO:0006805xenobiotic metabolic process
BPIBAGO:0016042lipid catabolic process
BPTASGO:0034383low-density lipoprotein particle clearance

Gene expression in normal tissue: CES3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CES3

DatabasePathway IDPathway Des.
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
pide2f_pathwayE2F transcription factor network
reactomeR-HSA-174824Plasma lipoprotein assembly, remodeling, and clearance
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-8964038LDL clearance
reactomeR-HSA-8964043Plasma lipoprotein clearance

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CES3