CES3
Summary: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| carboxylesterase 3 | MIM:605279 | Ensembl:ENSG00000172828 | HGNC:HGNC:1865 | PA26418 | 16q22.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CES3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004771 | sterol esterase activity |
| MF | IBA | GO:0004806 | triglyceride lipase activity |
| MF | IBA | GO:0052689 | carboxylic ester hydrolase activity |
| MF | TAS | GO:0052689 | carboxylic ester hydrolase activity |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0006805 | xenobiotic metabolic process |
| BP | IBA | GO:0016042 | lipid catabolic process |
| BP | TAS | GO:0034383 | low-density lipoprotein particle clearance |
Gene expression in normal tissue: CES3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CES3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| pid | e2f_pathway | E2F transcription factor network |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-8964038 | LDL clearance |
| reactome | R-HSA-8964043 | Plasma lipoprotein clearance |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CES3
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