CHFR


Summary: This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
checkpoint with forkhead and ring finger domainsMIM:605209Ensembl:ENSG00000072609HGNC:HGNC:20455PA13489894912q24.33

Gene Categories:

TUMOR SUPPRESSOR

GO terms in CHFR


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000166nucleotide binding
MFIBAGO:0004842ubiquitin-protein transferase activity
MFIDAGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0061630ubiquitin protein ligase activity
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0016605PML body
BPIDAGO:0000209protein polyubiquitination
BPIBAGO:0006511ubiquitin-dependent protein catabolic process
BPIBAGO:0007093mitotic cell cycle checkpoint
BPIMPGO:0007093mitotic cell cycle checkpoint
BPTASGO:0007093mitotic cell cycle checkpoint
BPIBAGO:0016567protein ubiquitination
BPIDAGO:0019941modification-dependent protein catabolic process
BPIEAGO:0031398positive regulation of protein ubiquitination
BPIEAGO:0031648protein destabilization
BPIEAGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIEAGO:0051301cell division

Gene expression in normal tissue: CHFR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHFR


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHFR

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