Summary: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014].

chimerin 2MIM:602857Ensembl:ENSG00000285162HGNC:HGNC:1944PA264747p14.3

GO terms in CHN2

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0009967positive regulation of signal transduction
BPIEAGO:0035556intracellular signal transduction
BPIEAGO:0043547positive regulation of GTPase activity
BPTASGO:0051056regulation of small GTPase mediated signal transduction
MFTASGO:0005070SH3/SH2 adaptor activity
MFTASGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: CHN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHN2

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
piderbb1_downstream_pathwayErbB1 downstream signaling
pidrac1_reg_pathwayRegulation of RAC1 activity

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHN2