CHRNB2
Summary: Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cholinergic receptor nicotinic beta 2 subunit | MIM:118507 | Ensembl:ENSG00000160716 | HGNC:HGNC:1962 | PA115 | 1q21.3 |
GO terms in CHRNB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005892 | acetylcholine-gated channel complex |
| CC | IDA | GO:0005892 | acetylcholine-gated channel complex |
| CC | ISS | GO:0009897 | external side of plasma membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0043005 | neuron projection |
| CC | ISS | GO:0044853 | plasma membrane raft |
| CC | IBA | GO:0045202 | synapse |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| BP | IEA | GO:0001508 | action potential |
| BP | IEA | GO:0001661 | conditioned taste aversion |
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | NAS | GO:0006811 | ion transport |
| BP | ISS | GO:0006816 | calcium ion transport |
| BP | ISS | GO:0006939 | smooth muscle contraction |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IDA | GO:0007165 | signal transduction |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0007271 | synaptic transmission, cholinergic |
| BP | ISS | GO:0007271 | synaptic transmission, cholinergic |
| BP | IBA | GO:0007274 | neuromuscular synaptic transmission |
| BP | ISS | GO:0007601 | visual perception |
| BP | ISS | GO:0007605 | sensory perception of sound |
| BP | IMP | GO:0007612 | learning |
| BP | IMP | GO:0007613 | memory |
| BP | ISS | GO:0007626 | locomotory behavior |
| BP | ISS | GO:0008306 | associative learning |
| BP | IMP | GO:0008542 | visual learning |
| BP | ISS | GO:0014059 | regulation of dopamine secretion |
| BP | ISS | GO:0019233 | sensory perception of pain |
| BP | ISS | GO:0021562 | vestibulocochlear nerve development |
| BP | ISS | GO:0021631 | optic nerve morphogenesis |
| BP | ISS | GO:0021771 | lateral geniculate nucleus development |
| BP | ISS | GO:0021952 | central nervous system projection neuron axonogenesis |
| BP | ISS | GO:0030890 | positive regulation of B cell proliferation |
| BP | ISS | GO:0032225 | regulation of synaptic transmission, dopaminergic |
| BP | IEA | GO:0032226 | positive regulation of synaptic transmission, dopaminergic |
| BP | ISS | GO:0033603 | positive regulation of dopamine secretion |
| BP | IBA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IBA | GO:0035094 | response to nicotine |
| BP | IDA | GO:0035094 | response to nicotine |
| BP | IMP | GO:0035095 | behavioral response to nicotine |
| BP | ISS | GO:0035176 | social behavior |
| BP | ISS | GO:0042053 | regulation of dopamine metabolic process |
| BP | ISS | GO:0042113 | B cell activation |
| BP | ISS | GO:0042220 | response to cocaine |
| BP | ISS | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | IEA | GO:0045188 | regulation of circadian sleep/wake cycle, non-REM sleep |
| BP | ISS | GO:0045471 | response to ethanol |
| BP | ISS | GO:0045759 | negative regulation of action potential |
| BP | ISS | GO:0048814 | regulation of dendrite morphogenesis |
| BP | IBA | GO:0050877 | nervous system process |
| BP | IMP | GO:0050877 | nervous system process |
| BP | IMP | GO:0050890 | cognition |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | ISS | GO:0051899 | membrane depolarization |
| BP | ISS | GO:0051963 | regulation of synapse assembly |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | ISS | GO:0060084 | synaptic transmission involved in micturition |
| BP | ISS | GO:0095500 | acetylcholine receptor signaling pathway |
| BP | ISS | GO:1905144 | response to acetylcholine |
| MF | IBA | GO:0005230 | extracellular ligand-gated ion channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015276 | ligand-gated ion channel activity |
| MF | IBA | GO:0015464 | acetylcholine receptor activity |
| MF | IDA | GO:0015464 | acetylcholine receptor activity |
| MF | IDA | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | ISS | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | TAS | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | IBA | GO:0042166 | acetylcholine binding |
| MF | IC | GO:0042166 | acetylcholine binding |
| MF | IMP | GO:0042166 | acetylcholine binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: CHRNB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHRNB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-181431 | Acetylcholine binding and downstream events |
| reactome | R-HSA-622323 | Presynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-622327 | Postsynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-629587 | Highly sodium permeable acetylcholine nicotinic receptors |
| reactome | R-HSA-629594 | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-629597 | Highly calcium permeable nicotinic acetylcholine receptors |
| reactome | R-HSA-629602 | Activation of Nicotinic Acetylcholine Receptors |
| wikipathways | WP1602 | Nicotine Activity on Dopaminergic Neurons |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| smpdb | SMP00392 | Benzocaine Action Pathway |
| smpdb | SMP00393 | Bupivacaine Action Pathway |
| smpdb | SMP00394 | Chloroprocaine Action Pathway |
| smpdb | SMP00395 | Cocaine Action Pathway |
| smpdb | SMP00396 | Dibucaine Action Pathway |
| smpdb | SMP00397 | Levobupivacaine Action Pathway |
| smpdb | SMP00398 | Lidocaine (Local Anaesthetic) Action Pathway |
| smpdb | SMP00399 | Mepivacaine Action Pathway |
| smpdb | SMP00400 | Oxybuprocaine Action Pathway |
| smpdb | SMP00401 | Prilocaine Action Pathway |
| smpdb | SMP00402 | Procaine Action Pathway |
| smpdb | SMP00403 | Proparacaine Action Pathway |
| smpdb | SMP00404 | Ropivacaine Action Pathway |
| smpdb | SMP00405 | Codeine Action Pathway |
| smpdb | SMP00406 | Morphine Action Pathway |
| smpdb | SMP00407 | Heroin Action Pathway |
| smpdb | SMP00408 | Methadone Action Pathway |
| smpdb | SMP00409 | Oxycodone Action Pathway |
| smpdb | SMP00410 | Hydromorphone Action Pathway |
| smpdb | SMP00411 | Hydrocodone Action Pathway |
| smpdb | SMP00412 | Oxymorphone Action Pathway |
| smpdb | SMP00413 | Alfentanil Action Pathway |
| smpdb | SMP00414 | Carfentanil Action Pathway |
| smpdb | SMP00415 | Fentanyl Action Pathway |
| smpdb | SMP00416 | Remifentanil Action Pathway |
| smpdb | SMP00417 | Sufentanil Action Pathway |
| smpdb | SMP00422 | Imipramine Action Pathway |
| smpdb | SMP00423 | Desipramine Action Pathway |
| smpdb | SMP00424 | Citalopram Action Pathway |
| smpdb | SMP00425 | Escitalopram Action Pathway |
| smpdb | SMP00426 | Fluoxetine Action Pathway |
| smpdb | SMP00431 | Nicotine Action Pathway |
| smpdb | SMP00628 | Nicotine Metabolism Pathway |
| smpdb | SMP00671 | Tramadol Action Action Pathway |
| smpdb | SMP00672 | Propoxyphene Action Pathway |
| smpdb | SMP00673 | Levorphanol Action Pathway |
| smpdb | SMP00674 | Anileridine Action Pathway |
| smpdb | SMP00675 | Diphenoxylate Action Pathway |
| smpdb | SMP00676 | Dezocine Action Pathway |
| smpdb | SMP00677 | Levomethadyl Acetate Action Action Pathway |
| smpdb | SMP00678 | Methadyl Acetate Action Pathway |
| smpdb | SMP00679 | 3-Methylthiofentanyl Action Pathway |
| smpdb | SMP00680 | Dimethylthiambutene Action Pathway |
| smpdb | SMP00681 | Ethylmorphine Action Pathway |
| smpdb | SMP00683 | Levallorphan Action Pathway |
| smpdb | SMP00684 | Buprenorphine Action Pathway |
| smpdb | SMP00685 | Alvimopan Action Pathway |
| smpdb | SMP00686 | Pentazocine Action Pathway |
| smpdb | SMP00687 | Naltrexone Action Pathway |
| smpdb | SMP00688 | Naloxone Action Pathway |
| smpdb | SMP00689 | Dihydromorphine Action Pathway |
| smpdb | SMP00690 | Ketobemidone Action Pathway |
| smpdb | SMP00691 | Nalbuphine Action Pathway |
| pharmgkb | PA162355621 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa05033 | Nicotine addiction - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHRNB2
CLASSFICATION
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