CLASP2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cytoplasmic linker associated protein 2 | MIM:605853 | Ensembl:ENSG00000163539 | HGNC:HGNC:17078 | PA38435 | 3p22.3 |
GO terms in CLASP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0002162 | dystroglycan binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | IDA | GO:0051010 | microtubule plus-end binding |
| BP | IMP | GO:0000226 | microtubule cytoskeleton organization |
| BP | IMP | GO:0006903 | vesicle targeting |
| BP | IMP | GO:0007020 | microtubule nucleation |
| BP | NAS | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | IMP | GO:0007052 | mitotic spindle organization |
| BP | TAS | GO:0007163 | establishment or maintenance of cell polarity |
| BP | IMP | GO:0010458 | exit from mitosis |
| BP | IMP | GO:0010470 | regulation of gastrulation |
| BP | IMP | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IMP | GO:0010717 | regulation of epithelial to mesenchymal transition |
| BP | IMP | GO:0031023 | microtubule organizing center organization |
| BP | IMP | GO:0031110 | regulation of microtubule polymerization or depolymerization |
| BP | IMP | GO:0032886 | regulation of microtubule-based process |
| BP | IMP | GO:0034453 | microtubule anchoring |
| BP | IMP | GO:0045921 | positive regulation of exocytosis |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0051497 | negative regulation of stress fiber assembly |
| BP | IMP | GO:0051895 | negative regulation of focal adhesion assembly |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | IMP | GO:0090091 | positive regulation of extracellular matrix disassembly |
| BP | IMP | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells |
| BP | IMP | GO:1904261 | positive regulation of basement membrane assembly involved in embryonic body morphogenesis |
| CC | IMP | GO:0000776 | kinetochore |
| CC | IEA | GO:0000777 | condensed chromosome kinetochore |
| CC | NAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | TAS | GO:0005828 | kinetochore microtubule |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005874 | microtubule |
| CC | IDA | GO:0005874 | microtubule |
| CC | IDA | GO:0005881 | cytoplasmic microtubule |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005938 | cell cortex |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0031252 | cell leading edge |
| CC | IDA | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0045180 | basal cortex |
| CC | IMP | GO:0072686 | mitotic spindle |
Gene expression in normal tissue: CLASP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLASP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428890 | Role of ABL in ROBO-SLIT signaling |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLASP2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.