CLDN12
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| claudin 12 | MIM:611232 | Ensembl:ENSG00000157224 | HGNC:HGNC:2034 | PA26560 | 7q21.13 |
GO terms in CLDN12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0042802 | identical protein binding |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005923 | bicellular tight junction |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016328 | lateral plasma membrane |
| BP | ISS | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules |
Gene expression in normal tissue: CLDN12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLDN12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-420029 | Tight junction interactions |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLDN12
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