CNIH2
Summary: The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
cornichon family AMPA receptor auxiliary protein 2 | MIM:611288 | Ensembl:ENSG00000174871 | HGNC:HGNC:28744 | PA134887358 | 11q13.2 |
GO terms in CNIH2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IEA | GO:0000139 | Golgi membrane |
CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
CC | TAS | GO:0012507 | ER to Golgi transport vesicle membrane |
CC | ISS | GO:0014069 | postsynaptic density |
CC | IEA | GO:0030054 | cell junction |
CC | ISS | GO:0030425 | dendrite |
CC | ISS | GO:0032281 | AMPA glutamate receptor complex |
CC | TAS | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
CC | ISS | GO:0043197 | dendritic spine |
CC | ISS | GO:0043198 | dendritic shaft |
CC | ISS | GO:0045211 | postsynaptic membrane |
BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
BP | IEA | GO:0035249 | synaptic transmission, glutamatergic |
BP | IEA | GO:0042391 | regulation of membrane potential |
BP | TAS | GO:0048208 | COPII vesicle coating |
BP | IEA | GO:0051668 | localization within membrane |
BP | IEA | GO:1902684 | negative regulation of receptor localization to synapse |
BP | IEA | GO:1903743 | negative regulation of anterograde synaptic vesicle transport |
BP | IEA | GO:2000310 | regulation of NMDA receptor activity |
BP | IDA | GO:2000311 | regulation of AMPA receptor activity |
MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: CNIH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CNIH2
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
reactome | R-HSA-199991 | Membrane Trafficking |
reactome | R-HSA-204005 | COPII-mediated vesicle transport |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
reactome | R-HSA-5653656 | Vesicle-mediated transport |
reactome | R-HSA-5694530 | Cargo concentration in the ER |
reactome | R-HSA-597592 | Post-translational protein modification |
reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in CNIH2