CNTFR


Summary: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ciliary neurotrophic factor receptorMIM:118946Ensembl:ENSG00000122756HGNC:HGNC:2170PA266849p13.3

Gene Categories:

DRUGGABLE GENOME

GO terms in CNTFR


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004896cytokine receptor activity
MFIBAGO:0004897ciliary neurotrophic factor receptor activity
MFIDAGO:0004897ciliary neurotrophic factor receptor activity
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0019955cytokine binding
MFIPIGO:0019955cytokine binding
MFIBAGO:0045523interleukin-27 receptor binding
BPIEAGO:0001967suckling behavior
BPIEAGO:0003360brainstem development
BPNASGO:0007165signal transduction
BPTASGO:0007399nervous system development
BPIEAGO:0007548sex differentiation
BPIEAGO:0008284positive regulation of cell proliferation
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0060538skeletal muscle organ development
BPIDAGO:0070120ciliary neurotrophic factor-mediated signaling pathway
CCTASGO:0005886plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCIDAGO:0016324apical plasma membrane
CCTASGO:0019898extrinsic component of membrane
CCIEAGO:0031225anchored component of membrane
CCIBAGO:0043235receptor complex
CCIBAGO:0070110ciliary neurotrophic factor receptor complex
CCIDAGO:0070110ciliary neurotrophic factor receptor complex
CCIBAGO:0097059CNTFR-CLCF1 complex
CCIDAGO:0097059CNTFR-CLCF1 complex

Gene expression in normal tissue: CNTFR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CNTFR


DatabasePathway IDPathway Des.
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
wikipathwaysWP236Adipogenesis
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6783589Interleukin-6 family signaling
reactomeR-HSA-6788467IL-6-type cytokine receptor ligand interactions

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CNTFR

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