CNTN4
Summary: This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| contactin 4 | MIM:607280 | Ensembl:ENSG00000144619 | HGNC:HGNC:2174 | PA26688 | 3p26.3-p26.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CNTN4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007158 | neuron cell-cell adhesion |
| BP | IMP | GO:0007399 | nervous system development |
| BP | TAS | GO:0007409 | axonogenesis |
| BP | TAS | GO:0007411 | axon guidance |
| BP | TAS | GO:0007413 | axonal fasciculation |
| BP | ISS | GO:0007420 | brain development |
| BP | ISS | GO:0031175 | neuron projection development |
| BP | IMP | GO:0045665 | negative regulation of neuron differentiation |
| BP | TAS | GO:0048167 | regulation of synaptic plasticity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | NAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0030424 | axon |
| CC | IEA | GO:0031225 | anchored component of membrane |
Gene expression in normal tissue: CNTN4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CNTN4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CNTN4
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