COMT
Summary: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| catechol-O-methyltransferase | MIM:116790 | Ensembl:ENSG00000093010 | HGNC:HGNC:2228 | PA117 | 22q11.21 |
GO terms in COMT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008168 | methyltransferase activity |
| MF | IBA | GO:0008171 | O-methyltransferase activity |
| MF | TAS | GO:0008171 | O-methyltransferase activity |
| MF | IBA | GO:0016206 | catechol O-methyltransferase activity |
| MF | IDA | GO:0016206 | catechol O-methyltransferase activity |
| MF | TAS | GO:0016206 | catechol O-methyltransferase activity |
| MF | IEA | GO:0102084 | L-dopa O-methyltransferase activity |
| MF | IEA | GO:0102938 | orcinol O-methyltransferase activity |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0007612 | learning |
| BP | IEA | GO:0007614 | short-term memory |
| BP | IEA | GO:0008210 | estrogen metabolic process |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IEA | GO:0016036 | cellular response to phosphate starvation |
| BP | TAS | GO:0032259 | methylation |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IBA | GO:0032502 | developmental process |
| BP | IEA | GO:0032502 | developmental process |
| BP | IEA | GO:0035814 | negative regulation of renal sodium excretion |
| BP | IEA | GO:0042135 | neurotransmitter catabolic process |
| BP | IBA | GO:0042417 | dopamine metabolic process |
| BP | IEA | GO:0042420 | dopamine catabolic process |
| BP | IBA | GO:0042424 | catecholamine catabolic process |
| BP | IDA | GO:0042424 | catecholamine catabolic process |
| BP | IEA | GO:0042493 | response to drug |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | IEA | GO:0045963 | negative regulation of dopamine metabolic process |
| BP | IEA | GO:0048265 | response to pain |
| BP | IEA | GO:0048609 | multicellular organismal reproductive process |
| BP | IEA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0050668 | positive regulation of homocysteine metabolic process |
| BP | IEA | GO:0051930 | regulation of sensory perception of pain |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0030424 | axon |
| CC | IEA | GO:0030424 | axon |
| CC | IBA | GO:0030425 | dendrite |
| CC | IEA | GO:0043197 | dendritic spine |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0044297 | cell body |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: COMT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in COMT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112311 | Neurotransmitter clearance |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156581 | Methylation |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-379397 | Enzymatic degradation of dopamine by COMT |
| reactome | R-HSA-379398 | Enzymatic degradation of Dopamine by monoamine oxidase |
| reactome | R-HSA-379401 | Dopamine clearance from the synaptic cleft |
| humancyc | PWY-6334 | L-dopa degradation |
| humancyc | PWY-6342 | noradrenaline and adrenaline degradation |
| humancyc | PWY6666-2 | dopamine degradation |
| pharmgkb | PA145011115 | Phenytoin Pathway, Pharmacokinetics |
| pharmgkb | PA145011118 | Estrogen Metabolism Pathway |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa00350 | Tyrosine metabolism - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| wikipathways | WP2436 | Dopamine metabolism |
| wikipathways | WP550 | Biogenic Amine Synthesis |
| wikipathways | WP697 | Estrogen metabolism |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| wikipathways | WP704 | Methylation Pathways |
| smpdb | SMP00006 | Tyrosine Metabolism |
| smpdb | SMP00169 | Alkaptonuria |
| smpdb | SMP00190 | Hawkinsinuria |
| smpdb | SMP00218 | Tyrosinemia Type I |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00429 | Disulfiram Action Pathway |
| smpdb | SMP00494 | Tyrosinemia, transient, of the newborn |
| smpdb | SMP00498 | Dopamine beta-hydroxylase deficiency |
| smpdb | SMP00533 | Monoamine oxidase-a deficiency (MAO-A) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in COMT
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.