COQ7
Summary: The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| coenzyme Q7, hydroxylase | MIM:601683 | Ensembl:ENSG00000167186 | HGNC:HGNC:2244 | PA26761 | 16p12.3 |
GO terms in COQ7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006744 | ubiquinone biosynthetic process |
| BP | IEA | GO:0006744 | ubiquinone biosynthetic process |
| BP | IBA | GO:0042775 | mitochondrial ATP synthesis coupled electron transport |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005743 | mitochondrial inner membrane |
| CC | IEA | GO:0005743 | mitochondrial inner membrane |
| MF | IEA | GO:0004497 | monooxygenase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: COQ7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in COQ7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-2142789 | Ubiquinol biosynthesis |
| reactome | R-HSA-8978934 | Metabolism of cofactors |
| humancyc | PWY-5872 | ubiquinol-10 biosynthesis |
| kegg | hsa00130 | Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human) |
| smpdb | SMP00065 | Ubiquinone Biosynthesis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in COQ7
CLASSFICATION
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