COX6C
Summary: Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
cytochrome c oxidase subunit 6C | MIM:124090 | Ensembl:ENSG00000164919 | HGNC:HGNC:2285 | PA26802 | 8q22.2 |
Gene Categories:
TRANSPORTERGO terms in COX6C
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0004129 | cytochrome-c oxidase activity |
CC | IDA | GO:0005739 | mitochondrion |
CC | TAS | GO:0005743 | mitochondrial inner membrane |
CC | IEA | GO:0016021 | integral component of membrane |
BP | TAS | GO:0006091 | generation of precursor metabolites and energy |
BP | IEA | GO:0022900 | electron transport chain |
BP | IEA | GO:1902600 | proton transmembrane transport |
Gene expression in normal tissue: COX6C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in COX6C
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-163200 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
reactome | R-HSA-212436 | Generic Transcription Pathway |
reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
reactome | R-HSA-611105 | Respiratory electron transport |
reactome | R-HSA-73857 | RNA Polymerase II Transcription |
reactome | R-HSA-74160 | Gene expression (Transcription) |
wikipathways | WP111 | Electron Transport Chain |
kegg | hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
kegg | hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in COX6C