Summary: Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010].

cytochrome c oxidase subunit 6CMIM:124090Ensembl:ENSG00000164919HGNC:HGNC:2285PA268028q22.2

Gene Categories:


GO terms in COX6C

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004129cytochrome-c oxidase activity
CCTASGO:0005743mitochondrial inner membrane
CCIEAGO:0016021integral component of membrane
BPTASGO:0006091generation of precursor metabolites and energy
BPIEAGO:0022900electron transport chain
BPIEAGO:1902600proton transmembrane transport

Gene expression in normal tissue: COX6C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COX6C

DatabasePathway IDPathway Des.
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-611105Respiratory electron transport
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
wikipathwaysWP111Electron Transport Chain
kegghsa00190Oxidative phosphorylation - Homo sapiens (human)
kegghsa04260Cardiac muscle contraction - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05012Parkinson,s disease - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD885Compound 1104

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COX6C