CPT1C
Summary: This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
carnitine palmitoyltransferase 1C | MIM:608846 | Ensembl:ENSG00000169169 | HGNC:HGNC:18540 | PA134922321 | 19q13.33 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CPT1C
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004095 | carnitine O-palmitoyltransferase activity |
MF | IEA | GO:0004095 | carnitine O-palmitoyltransferase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0008374 | O-acyltransferase activity |
BP | IBA | GO:0006631 | fatty acid metabolic process |
BP | IEA | GO:0006635 | fatty acid beta-oxidation |
BP | IBA | GO:0009437 | carnitine metabolic process |
BP | IEA | GO:0009437 | carnitine metabolic process |
BP | IBA | GO:0015909 | long-chain fatty acid transport |
CC | IBA | GO:0005739 | mitochondrion |
CC | IEA | GO:0005741 | mitochondrial outer membrane |
CC | ISS | GO:0005783 | endoplasmic reticulum |
CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
CC | IEA | GO:0030054 | cell junction |
CC | ISS | GO:0030424 | axon |
CC | ISS | GO:0030425 | dendrite |
CC | IEA | GO:0032281 | AMPA glutamate receptor complex |
CC | IEA | GO:0045202 | synapse |
Gene expression in normal tissue: CPT1C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CPT1C
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
kegg | hsa00071 | Fatty acid degradation - Homo sapiens (human) |
kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
humancyc | PWY-6111 | mitochondrial L-carnitine shuttle |
wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
wikipathways | WP3942 | PPAR signaling pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CPT1C