CPT1C


Summary: This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
carnitine palmitoyltransferase 1CMIM:608846Ensembl:ENSG00000169169HGNC:HGNC:18540PA13492232119q13.33

Gene Categories:

DRUGGABLE GENOME

GO terms in CPT1C


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004095carnitine O-palmitoyltransferase activity
MFIEAGO:0004095carnitine O-palmitoyltransferase activity
MFIPIGO:0005515protein binding
MFIBAGO:0008374O-acyltransferase activity
BPIBAGO:0006631fatty acid metabolic process
BPIEAGO:0006635fatty acid beta-oxidation
BPIBAGO:0009437carnitine metabolic process
BPIEAGO:0009437carnitine metabolic process
BPIBAGO:0015909long-chain fatty acid transport
CCIBAGO:0005739mitochondrion
CCIEAGO:0005741mitochondrial outer membrane
CCISSGO:0005783endoplasmic reticulum
CCIEAGO:0005789endoplasmic reticulum membrane
CCIEAGO:0030054cell junction
CCISSGO:0030424axon
CCISSGO:0030425dendrite
CCIEAGO:0032281AMPA glutamate receptor complex
CCIEAGO:0045202synapse

Gene expression in normal tissue: CPT1C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CPT1C


DatabasePathway IDPathway Des.
pidhnf3bpathwayFOXA2 and FOXA3 transcription factor networks
kegghsa00071Fatty acid degradation - Homo sapiens (human)
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
humancycPWY-6111mitochondrial L-carnitine shuttle
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP3942PPAR signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CPT1C

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