Summary: This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].

complement C3d receptor 2MIM:120650Ensembl:ENSG00000117322HGNC:HGNC:2336PA268571q32.2

Gene Categories:


GO terms in CR2

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFIDAGO:0001848complement binding
MFIDAGO:0003677DNA binding
MFNASGO:0004875complement receptor activity
MFNASGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIDAGO:0042803protein homodimerization activity
CCTASGO:0005886plasma membrane
CCNASGO:0016021integral component of membrane
CCIDAGO:0043235receptor complex
CCHDAGO:0070062extracellular exosome
BPIEAGO:0002430complement receptor mediated signaling pathway
BPNASGO:0006955immune response
BPIEAGO:0006958complement activation, classical pathway
BPIDAGO:0030183B cell differentiation
BPTASGO:0030449regulation of complement activation
BPIDAGO:0042100B cell proliferation
BPIEAGO:0045087innate immune response
BPIEAGO:0046718viral entry into host cell

Gene expression in normal tissue: CR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CR2

DatabasePathway IDPathway Des.
reactomeR-HSA-166658Complement cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-977606Regulation of Complement cascade
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2806Human Complement System
wikipathwaysWP3896Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP558Complement and Coagulation Cascades
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CR2