CRMP1
Summary: This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| collapsin response mediator protein 1 | MIM:602462 | Ensembl:ENSG00000072832 | HGNC:HGNC:2365 | PA26885 | 4p16.2 |
GO terms in CRMP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000226 | microtubule cytoskeleton organization |
| BP | TAS | GO:0006139 | nucleobase-containing compound metabolic process |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IEA | GO:0007411 | axon guidance |
| BP | IGI | GO:0010977 | negative regulation of neuron projection development |
| BP | IDA | GO:1904530 | negative regulation of actin filament binding |
| BP | IMP | GO:1904530 | negative regulation of actin filament binding |
| CC | IDA | GO:0005813 | centrosome |
| CC | IEA | GO:0005819 | spindle |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0030496 | midbody |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| MF | IPI | GO:0031005 | filamin binding |
Gene expression in normal tissue: CRMP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CRMP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-399956 | CRMPs in Sema3A signaling |
| reactome | R-HSA-422475 | Axon guidance |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CRMP1
CLASSFICATION
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