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CTNNA1

Summary: This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
catenin alpha 1	MIM:116805	Ensembl:ENSG00000044115	HGNC:HGNC:2509	PA27008	5q31.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in CTNNA1

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0001669	acrosomal vesicle
CC	IDA	GO:0005794	Golgi apparatus
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IDA	GO:0005911	cell-cell junction
CC	IEA	GO:0005915	zonula adherens
CC	HDA	GO:0005925	focal adhesion
CC	IEA	GO:0014704	intercalated disc
CC	IEA	GO:0015629	actin cytoskeleton
CC	IDA	GO:0016342	catenin complex
CC	IEA	GO:0016600	flotillin complex
CC	IEA	GO:0030027	lamellipodium
CC	IDA	GO:0030054	cell junction
CC	IDA	GO:0043231	intracellular membrane-bounded organelle
BP	IEA	GO:0001541	ovarian follicle development
BP	IEA	GO:0007015	actin filament organization
BP	NAS	GO:0007155	cell adhesion
BP	IEA	GO:0007163	establishment or maintenance of cell polarity
BP	IEA	GO:0007406	negative regulation of neuroblast proliferation
BP	IEA	GO:0007568	aging
BP	IEA	GO:0008584	male gonad development
BP	IEA	GO:0016264	gap junction assembly
BP	IEA	GO:0031103	axon regeneration
BP	TAS	GO:0034332	adherens junction organization
BP	IEA	GO:0034613	cellular protein localization
BP	IEA	GO:0042475	odontogenesis of dentin-containing tooth
BP	NAS	GO:0043297	apical junction assembly
BP	IEA	GO:0043627	response to estrogen
BP	IEA	GO:0045880	positive regulation of smoothened signaling pathway
BP	TAS	GO:0051149	positive regulation of muscle cell differentiation
BP	IEA	GO:0051291	protein heterooligomerization
BP	IDA	GO:0071681	cellular response to indole-3-methanol
BP	IEA	GO:0090136	epithelial cell-cell adhesion
BP	IEA	GO:2000146	negative regulation of cell motility
BP	IEA	GO:2001045	negative regulation of integrin-mediated signaling pathway
BP	IEA	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
BP	IEA	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
MF	HDA	GO:0003723	RNA binding
MF	IEA	GO:0005198	structural molecule activity
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0008013	beta-catenin binding
MF	IPI	GO:0017166	vinculin binding
MF	IPI	GO:0042802	identical protein binding
MF	IPI	GO:0045295	gamma-catenin binding
MF	HDA	GO:0045296	cadherin binding
MF	IPI	GO:0045296	cadherin binding
MF	IEA	GO:0046982	protein heterodimerization activity
MF	IEA	GO:0051015	actin filament binding

Gene expression in normal tissue: CTNNA1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CTNNA1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1500931	Cell-Cell communication
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-194138	Signaling by VEGF
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-195258	RHO GTPase Effectors
reactome	R-HSA-375170	CDO in myogenesis
reactome	R-HSA-375170	CDO in myogenesis
reactome	R-HSA-418990	Adherens junctions interactions
reactome	R-HSA-421270	Cell-cell junction organization
reactome	R-HSA-4420097	VEGFA-VEGFR2 Pathway
reactome	R-HSA-446728	Cell junction organization
reactome	R-HSA-5218920	VEGFR2 mediated vascular permeability
reactome	R-HSA-525793	Myogenesis
reactome	R-HSA-525793	Myogenesis
reactome	R-HSA-5626467	RHO GTPases activate IQGAPs
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
wikipathways	WP2118	Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathways	WP2864	Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP3946	White fat cell differentiation
wikipathways	WP4149	White fat cell differentiation
wikipathways	WP4155	Endometrial cancer
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
pid	ajdiss_2pathway	Posttranslational regulation of adherens junction stability and dissassembly
pid	arf6_traffickingpathway	Arf6 trafficking events
pid	cdc42_pathway	CDC42 signaling events
pid	ecadherin_keratinocyte_pathway	E-cadherin signaling in keratinocytes
pid	ecadherin_nascentaj_pathway	E-cadherin signaling in the nascent adherens junction
pid	ecadherin_stabilization_pathway	Stabilization and expansion of the E-cadherin adherens junction
pid	met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pid	ncadherinpathway	N-cadherin signaling events
pid	nectin_pathway	Nectin adhesion pathway
pid	rac1_pathway	RAC1 signaling pathway
pid	vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2
kegg	hsa04390	Hippo signaling pathway - Homo sapiens (human)
kegg	hsa04520	Adherens junction - Homo sapiens (human)
kegg	hsa04670	Leukocyte transendothelial migration - Homo sapiens (human)
kegg	hsa05100	Bacterial invasion of epithelial cells - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05213	Endometrial cancer - Homo sapiens (human)
kegg	hsa05226	Gastric cancer - Homo sapiens (human)
kegg	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTNNA1

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DATATYPES

CLASSFICATION

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