Summary: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015].

cathepsin BMIM:116810Ensembl:ENSG00000164733HGNC:HGNC:2527PA270278p23.1

Gene Categories:


GO terms in CTSB

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004197cysteine-type endopeptidase activity
MFIDAGO:0004197cysteine-type endopeptidase activity
MFTASGO:0004252serine-type endopeptidase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005518collagen binding
MFIDAGO:0008233peptidase activity
MFIDAGO:0008234cysteine-type peptidase activity
MFIPIGO:0043394proteoglycan binding
BPIDAGO:0030574collagen catabolic process
BPTASGO:0030574collagen catabolic process
BPIEPGO:0030855epithelial cell differentiation
BPTASGO:0042981regulation of apoptotic process
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0046718viral entry into host cell
BPIEAGO:0050790regulation of catalytic activity
BPIBAGO:0051603proteolysis involved in cellular protein catabolic process
BPIDAGO:0051603proteolysis involved in cellular protein catabolic process
BPIEPGO:0097067cellular response to thyroid hormone stimulus
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCISSGO:0005615extracellular space
CCTASGO:0036021endolysosome lumen
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCTASGO:1904813ficolin-1-rich granule lumen

Gene expression in normal tissue: CTSB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CTSB

DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1442490Collagen degradation
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474290Collagen formation
reactomeR-HSA-1679131Trafficking and processing of endosomal TLR
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-2022090Assembly of collagen fibrils and other multimeric structures
reactomeR-HSA-2132295MHC class II antigen presentation
reactomeR-HSA-6798695Neutrophil degranulation
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04142Lysosome - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTSB