CTTN
Summary: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cortactin | MIM:164765 | Ensembl:ENSG00000085733 | HGNC:HGNC:3338 | PA27775 | 11q13.3 |
GO terms in CTTN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0005522 | profilin binding |
| MF | HDA | GO:0045296 | cadherin binding |
| CC | ISS | GO:0001726 | ruffle |
| CC | IEA | GO:0002102 | podosome |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0005884 | actin filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005905 | clathrin-coated pit |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005938 | cell cortex |
| CC | ISS | GO:0005938 | cell cortex |
| CC | IDA | GO:0008076 | voltage-gated potassium channel complex |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | ISS | GO:0030027 | lamellipodium |
| CC | ISS | GO:0030426 | growth cone |
| CC | IDA | GO:0030863 | cortical cytoskeleton |
| CC | IEA | GO:0043197 | dendritic spine |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:1990023 | mitotic spindle midzone |
| BP | IMP | GO:0006886 | intracellular protein transport |
| BP | ISS | GO:0006898 | receptor-mediated endocytosis |
| BP | IEA | GO:0006930 | substrate-dependent cell migration, cell extension |
| BP | IEA | GO:0030041 | actin filament polymerization |
| BP | ISS | GO:0030516 | regulation of axon extension |
| BP | IMP | GO:0030838 | positive regulation of actin filament polymerization |
| BP | ISS | GO:0030838 | positive regulation of actin filament polymerization |
| BP | ISS | GO:0031532 | actin cytoskeleton reorganization |
| BP | IMP | GO:0045987 | positive regulation of smooth muscle contraction |
| BP | ISS | GO:0048041 | focal adhesion assembly |
| BP | ISS | GO:0048812 | neuron projection morphogenesis |
| BP | ISS | GO:0048870 | cell motility |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IEA | GO:0097062 | dendritic spine maintenance |
| BP | ISS | GO:0097581 | lamellipodium organization |
| BP | IEA | GO:1903146 | regulation of autophagy of mitochondrion |
| BP | IEA | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
Gene expression in normal tissue: CTTN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTTN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | fgf_pathway | FGF signaling pathway |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD150 | RITA | 5 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTTN
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