CXCL8


Summary: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
C-X-C motif chemokine ligand 8MIM:146930Ensembl:ENSG00000169429HGNC:HGNC:6025PA298414q13.3

GO terms in CXCL8


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005153interleukin-8 receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008009chemokine activity
MFIDAGO:0008009chemokine activity
MFTASGO:0008009chemokine activity
MFIBAGO:0045236CXCR chemokine receptor binding
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIEAGO:0005622intracellular
BPTASGO:0001525angiogenesis
BPIDAGO:0002237response to molecule of bacterial origin
BPTASGO:0006935chemotaxis
BPIBAGO:0006954inflammatory response
BPTASGO:0006954inflammatory response
BPIBAGO:0006955immune response
BPIDAGO:0007050cell cycle arrest
BPTASGO:0007165signal transduction
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019722calcium-mediated signaling
BPIDAGO:0030155regulation of cell adhesion
BPIBAGO:0030593neutrophil chemotaxis
BPIDAGO:0030593neutrophil chemotaxis
BPIGIGO:0030593neutrophil chemotaxis
BPIBAGO:0030595leukocyte chemotaxis
BPIDAGO:0031623receptor internalization
BPIDAGO:0034976response to endoplasmic reticulum stress
BPIDAGO:0035556intracellular signal transduction
BPTASGO:0036499PERK-mediated unfolded protein response
BPIDAGO:0042119neutrophil activation
BPTASGO:0042119neutrophil activation
BPIEPGO:0044344cellular response to fibroblast growth factor stimulus
BPIDAGO:0045091regulation of single stranded viral RNA replication via double stranded DNA intermediate
BPIDAGO:0045744negative regulation of G-protein coupled receptor protein signaling pathway
BPIDAGO:0045766positive regulation of angiogenesis
BPIEPGO:0048566embryonic digestive tract development
BPIGIGO:0050930induction of positive chemotaxis
BPIBAGO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide
BPIBAGO:0070098chemokine-mediated signaling pathway
BPIBAGO:0071222cellular response to lipopolysaccharide
BPIDAGO:0071222cellular response to lipopolysaccharide
BPIEPGO:0071347cellular response to interleukin-1
BPIEPGO:0071356cellular response to tumor necrosis factor
BPTASGO:0090023positive regulation of neutrophil chemotaxis
BPIMPGO:2000535regulation of entry of bacterium into host cell

Gene expression in normal tissue: CXCL8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CXCL8


DatabasePathway IDPathway Des.
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05134Legionellosis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
pidap1_pathwayAP-1 transcription factor network
pidatf2_pathwayATF-2 transcription factor network
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidfra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidlysophospholipid_pathwayLPA receptor mediated events
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidsyndecan_3_pathwaySyndecan-3-mediated signaling events
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP262EBV LMP1 signaling
wikipathwaysWP2753ATF4 activates genes
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP3287Overview of nanoparticle effects
wikipathwaysWP3391Senescence-Associated Secretory Phenotype (SASP)
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
wikipathwaysWP75Toll-like Receptor Signaling Pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-380108Chemokine receptors bind chemokines
reactomeR-HSA-380994ATF4 activates genes
reactomeR-HSA-381042PERK regulates gene expression
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-8953897Cellular responses to external stimuli
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXCL8

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