CXXC4


Summary: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CXXC finger protein 4MIM:611645Ensembl:ENSG00000168772HGNC:HGNC:24593PA1349920164q24

GO terms in CXXC4


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003677DNA binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0030165PDZ domain binding
BPISSGO:0007352zygotic specification of dorsal/ventral axis
BPIEAGO:0016055Wnt signaling pathway
BPIDAGO:0030178negative regulation of Wnt signaling pathway
CCIDAGO:0005737cytoplasm
CCIDAGO:0031410cytoplasmic vesicle

Gene expression in normal tissue: CXXC4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CXXC4


DatabasePathway IDPathway Des.
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
wikipathwaysWP428Wnt Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXXC4

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