DDX39A


Summary: This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DExD-box helicase 39AEnsembl:ENSG00000123136HGNC:HGNC:17821PA2722619p13.12

GO terms in DDX39A


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFEXPGO:0016887ATPase activity
MFIPIGO:0042802identical protein binding
BPIGIGO:0000398mRNA splicing, via spliceosome
BPTASGO:0006405RNA export from nucleus
BPIGIGO:0006406mRNA export from nucleus
BPTASGO:0031124mRNA 3'-end processing
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCHDAGO:0016020membrane
CCIDAGO:0016607nuclear speck

Gene expression in normal tissue: DDX39A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDX39A


DatabasePathway IDPathway Des.
reactomeR-HSA-109688Cleavage of Growing Transcript in the Termination Region
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-72187mRNA 3'-end processing
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-73856RNA Polymerase II Transcription Termination
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDX39A

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