Summary: This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011].

DExD-box helicase 39BMIM:142560Ensembl:ENSG00000198563HGNC:HGNC:13917PA252626p21.33

Gene Categories:


GO terms in DDX39B

Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIDAGO:0004004ATP-dependent RNA helicase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008186RNA-dependent ATPase activity
MFEXPGO:0016887ATPase activity
MFIDAGO:0017070U6 snRNA binding
MFIDAGO:0030621U4 snRNA binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0043008ATP-dependent protein binding
MFIEAGO:0044877protein-containing complex binding
CCIDAGO:0000346transcription export complex
CCIDAGO:0005681spliceosomal complex
CCIDAGO:0005687U4 snRNP
CCIDAGO:0005688U6 snRNP
CCIEAGO:0016363nuclear matrix
CCIDAGO:0016607nuclear speck
BPIDAGO:0000245spliceosomal complex assembly
BPIGIGO:0000398mRNA splicing, via spliceosome
BPIEAGO:0001889liver development
BPTASGO:0006405RNA export from nucleus
BPIDAGO:0006406mRNA export from nucleus
BPIGIGO:0006406mRNA export from nucleus
BPIDAGO:0008380RNA splicing
BPIDAGO:0010501RNA secondary structure unwinding
BPTASGO:0031124mRNA 3'-end processing
BPIMPGO:0032786positive regulation of DNA-templated transcription, elongation
BPIEAGO:0045727positive regulation of translation
BPIDAGO:0046784viral mRNA export from host cell nucleus
BPIEAGO:0061051positive regulation of cell growth involved in cardiac muscle cell development
BPIEAGO:1904707positive regulation of vascular smooth muscle cell proliferation
BPIMPGO:2000002negative regulation of DNA damage checkpoint
BPIEAGO:2000573positive regulation of DNA biosynthetic process

Gene expression in normal tissue: DDX39B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDX39B

DatabasePathway IDPathway Des.
kegghsa03013RNA transport - Homo sapiens (human)
kegghsa03015mRNA surveillance pathway - Homo sapiens (human)
kegghsa03040Spliceosome - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
reactomeR-HSA-109688Cleavage of Growing Transcript in the Termination Region
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-72187mRNA 3'-end processing
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-73856RNA Polymerase II Transcription Termination
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDX39B