Summary: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].

DEAD-box helicase 3 X-linkedMIM:300160Ensembl:ENSG00000215301HGNC:HGNC:2745PA27216Xp11.4

GO terms in DDX3X

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003677DNA binding
MFHDAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFIDAGO:0003924GTPase activity
MFIDAGO:0004003ATP-dependent DNA helicase activity
MFIDAGO:0004004ATP-dependent RNA helicase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008134transcription factor binding
MFIDAGO:0008143poly(A) binding
MFIDAGO:0008190eukaryotic initiation factor 4E binding
MFIDAGO:0016887ATPase activity
MFIDAGO:0017111nucleoside-triphosphatase activity
MFIDAGO:0031369translation initiation factor binding
MFIDAGO:0033592RNA strand annealing activity
MFIDAGO:0035613RNA stem-loop binding
MFIDAGO:0043024ribosomal small subunit binding
MFIDAGO:0043273CTPase activity
MFIDAGO:0043539protein serine/threonine kinase activator activity
MFHDAGO:0045296cadherin binding
MFIDAGO:0048027mRNA 5'-UTR binding
BPIEAGO:0006351transcription, DNA-templated
BPIMPGO:0006413translational initiation
BPIMPGO:0007059chromosome segregation
BPIMPGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIDAGO:0009615response to virus
BPIDAGO:0010501RNA secondary structure unwinding
BPIDAGO:0010628positive regulation of gene expression
BPIEAGO:0016032viral process
BPIMPGO:0016055Wnt signaling pathway
BPIMPGO:0017148negative regulation of translation
BPIMPGO:0030307positive regulation of cell growth
BPIDAGO:0030308negative regulation of cell growth
BPIDAGO:0031333negative regulation of protein complex assembly
BPIEAGO:0032508DNA duplex unwinding
BPTASGO:0032728positive regulation of interferon-beta production
BPIDAGO:0034063stress granule assembly
BPIDAGO:0035556intracellular signal transduction
BPIMPGO:0042256mature ribosome assembly
BPIMPGO:0043065positive regulation of apoptotic process
BPIMPGO:0043066negative regulation of apoptotic process
BPIMPGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIMPGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0043312neutrophil degranulation
BPIMPGO:0045070positive regulation of viral genome replication
BPIMPGO:0045087innate immune response
BPIDAGO:0045727positive regulation of translation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045948positive regulation of translational initiation
BPIDAGO:0071243cellular response to arsenic-containing substance
BPIDAGO:0071470cellular response to osmotic stress
BPTASGO:0071651positive regulation of chemokine (C-C motif) ligand 5 production
BPIDAGO:0071902positive regulation of protein serine/threonine kinase activity
BPIMPGO:0090263positive regulation of canonical Wnt signaling pathway
BPIMPGO:0097193intrinsic apoptotic signaling pathway
BPIMPGO:1900087positive regulation of G1/S transition of mitotic cell cycle
BPIMPGO:1903608protein localization to cytoplasmic stress granule
BPIMPGO:2001243negative regulation of intrinsic apoptotic signaling pathway
CCTASGO:0005576extracellular region
CCIEAGO:0005741mitochondrial outer membrane
CCIDAGO:0005852eukaryotic translation initiation factor 3 complex
CCIDAGO:0010494cytoplasmic stress granule
CCIEAGO:0016607nuclear speck
CCIDAGO:0022627cytosolic small ribosomal subunit
CCTASGO:0034774secretory granule lumen
CCHDAGO:0070062extracellular exosome
CCTASGO:1904813ficolin-1-rich granule lumen

Gene expression in normal tissue: DDX3X

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDX3X

DatabasePathway IDPathway Des.
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
wikipathwaysWP3865RIG-I-like Receptor Signaling
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD659Avagacestat (BMS-708163)1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDX3X