DGKH


Summary: This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
diacylglycerol kinase etaMIM:604071Ensembl:ENSG00000102780HGNC:HGNC:2854PA2731513q14.11

Gene Categories:

KINASE

GO terms in DGKH


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003951NAD+ kinase activity
MFIDAGO:0004143diacylglycerol kinase activity
MFIMPGO:0004143diacylglycerol kinase activity
MFTASGO:0004143diacylglycerol kinase activity
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding
CCIDAGO:0005737cytoplasm
CCIDAGO:0005768endosome
CCTASGO:0005886plasma membrane
BPIMPGO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway
BPIEAGO:0016310phosphorylation
BPTASGO:0030168platelet activation
BPIEAGO:0035556intracellular signal transduction
BPIDAGO:0046473phosphatidic acid metabolic process
BPIMPGO:0051259protein complex oligomerization

Gene expression in normal tissue: DGKH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DGKH


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114508Effects of PIP2 hydrolysis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-76002Platelet activation, signaling and aggregation
kegghsa00561Glycerolipid metabolism - Homo sapiens (human)
kegghsa00564Glycerophospholipid metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DGKH

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