DNAJB2
Summary: This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DnaJ heat shock protein family (Hsp40) member B2 | MIM:604139 | Ensembl:ENSG00000135924 | HGNC:HGNC:5228 | PA27415 | 2q35 |
GO terms in DNAJB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001671 | ATPase activator activity |
| MF | IDA | GO:0001671 | ATPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0030544 | Hsp70 protein binding |
| MF | IPI | GO:0030544 | Hsp70 protein binding |
| MF | IDA | GO:0043130 | ubiquitin binding |
| MF | IBA | GO:0051082 | unfolded protein binding |
| MF | IDA | GO:0051082 | unfolded protein binding |
| MF | IBA | GO:0051087 | chaperone binding |
| MF | IPI | GO:0051087 | chaperone binding |
| MF | IDA | GO:0140036 | ubiquitin-dependent protein binding |
| BP | TAS | GO:0006986 | response to unfolded protein |
| BP | IGI | GO:0008285 | negative regulation of cell proliferation |
| BP | IGI | GO:0030308 | negative regulation of cell growth |
| BP | IBA | GO:0030433 | ubiquitin-dependent ERAD pathway |
| BP | IMP | GO:0031396 | regulation of protein ubiquitination |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IBA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0032781 | positive regulation of ATPase activity |
| BP | IBA | GO:0042026 | protein refolding |
| BP | IDA | GO:0042026 | protein refolding |
| BP | IBA | GO:0061077 | chaperone-mediated protein folding |
| BP | IMP | GO:0061077 | chaperone-mediated protein folding |
| BP | TAS | GO:0070050 | neuron cellular homeostasis |
| BP | IDA | GO:0090084 | negative regulation of inclusion body assembly |
| BP | IDA | GO:1903644 | regulation of chaperone-mediated protein folding |
| CC | IBA | GO:0000502 | proteasome complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0031227 | intrinsic component of endoplasmic reticulum membrane |
| CC | IDA | GO:0031965 | nuclear membrane |
Gene expression in normal tissue: DNAJB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DNAJB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DNAJB2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.