Summary: This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011].

DnaJ heat shock protein family (Hsp40) member B2MIM:604139Ensembl:ENSG00000135924HGNC:HGNC:5228PA274152q35

GO terms in DNAJB2

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001671ATPase activator activity
MFIDAGO:0001671ATPase activator activity
MFIPIGO:0005515protein binding
MFIBAGO:0030544Hsp70 protein binding
MFIPIGO:0030544Hsp70 protein binding
MFIDAGO:0043130ubiquitin binding
MFIBAGO:0051082unfolded protein binding
MFIDAGO:0051082unfolded protein binding
MFIBAGO:0051087chaperone binding
MFIPIGO:0051087chaperone binding
MFIDAGO:0140036ubiquitin-dependent protein binding
BPTASGO:0006986response to unfolded protein
BPIGIGO:0008285negative regulation of cell proliferation
BPIGIGO:0030308negative regulation of cell growth
BPIBAGO:0030433ubiquitin-dependent ERAD pathway
BPIMPGO:0031396regulation of protein ubiquitination
BPIDAGO:0032091negative regulation of protein binding
BPIBAGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPTASGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIDAGO:0032781positive regulation of ATPase activity
BPIBAGO:0042026protein refolding
BPIDAGO:0042026protein refolding
BPIBAGO:0061077chaperone-mediated protein folding
BPIMPGO:0061077chaperone-mediated protein folding
BPTASGO:0070050neuron cellular homeostasis
BPIDAGO:0090084negative regulation of inclusion body assembly
BPIDAGO:1903644regulation of chaperone-mediated protein folding
CCIBAGO:0000502proteasome complex
CCIEAGO:0005789endoplasmic reticulum membrane
CCIBAGO:0031227intrinsic component of endoplasmic reticulum membrane
CCIDAGO:0031965nuclear membrane

Gene expression in normal tissue: DNAJB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DNAJB2

DatabasePathway IDPathway Des.
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DNAJB2