DNAJC6


Summary: DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DnaJ heat shock protein family (Hsp40) member C6MIM:608375Ensembl:ENSG00000116675HGNC:HGNC:15469PA274231p31.3

Gene Categories:

PROTEIN PHOSPHATASE

GO terms in DNAJC6


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004725protein tyrosine phosphatase activity
MFIEAGO:0017124SH3 domain binding
MFIBAGO:0030276clathrin binding
BPIBAGO:0006898receptor-mediated endocytosis
BPIBAGO:0016191synaptic vesicle uncoating
BPISSGO:0016191synaptic vesicle uncoating
BPIEAGO:0035335peptidyl-tyrosine dephosphorylation
BPTASGO:0061024membrane organization
BPIBAGO:0072318clathrin coat disassembly
BPIBAGO:0072583clathrin-dependent endocytosis
BPIEAGO:2000369regulation of clathrin-dependent endocytosis
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0014069postsynaptic density
CCIEAGO:0014069postsynaptic density
CCIBAGO:0031982vesicle
CCIBAGO:0043231intracellular membrane-bounded organelle

Gene expression in normal tissue: DNAJC6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DNAJC6


DatabasePathway IDPathway Des.
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199992trans-Golgi Network Vesicle Budding
reactomeR-HSA-421837Clathrin derived vesicle budding
reactomeR-HSA-432720Lysosome Vesicle Biogenesis
reactomeR-HSA-432722Golgi Associated Vesicle Biogenesis
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856828Clathrin-mediated endocytosis
kegghsa04144Endocytosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DNAJC6

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