DRAM1


Summary: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DNA damage regulated autophagy modulator 1MIM:610776Ensembl:ENSG00000136048HGNC:HGNC:25645PA16551256412q23.2

GO terms in DRAM1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
CCIDAGO:0005737cytoplasm
CCIBAGO:0005764lysosome
CCIDAGO:0005764lysosome
CCIEAGO:0005765lysosomal membrane
CCIEAGO:0016021integral component of membrane
BPIEAGO:0006914autophagy
BPIEAGO:0006915apoptotic process
BPIBAGO:0010506regulation of autophagy
BPIDAGO:0010506regulation of autophagy

Gene expression in normal tissue: DRAM1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DRAM1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DRAM1

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