DUT


Summary: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
deoxyuridine triphosphataseMIM:601266Ensembl:ENSG00000128951HGNC:HGNC:3078PA15115q21.1

Gene Categories:

DRUGGABLE GENOME

GO terms in DUT


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000287magnesium ion binding
MFHDAGO:0003723RNA binding
MFEXPGO:0004170dUTP diphosphatase activity
MFIBAGO:0004170dUTP diphosphatase activity
MFIPIGO:0005515protein binding
BPTASGO:0006139nucleobase-containing compound metabolic process
BPIBAGO:0006226dUMP biosynthetic process
BPIEAGO:0006226dUMP biosynthetic process
BPTASGO:0006260DNA replication
BPTASGO:0015949nucleobase-containing small molecule interconversion
BPIBAGO:0046081dUTP catabolic process
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005739mitochondrion
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: DUT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DUT


DatabasePathway IDPathway Des.
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-15869Metabolism of nucleotides
reactomeR-HSA-499943Interconversion of nucleotide di- and triphosphates
smpdbSMP00046Pyrimidine Metabolism
smpdbSMP00172Beta Ureidopropionase Deficiency
smpdbSMP00178Dihydropyrimidinase Deficiency
smpdbSMP00202MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
smpdbSMP00219UMP Synthase Deiciency (Orotic Aciduria)
wikipathwaysWP4022Pyrimidine metabolism
humancycPWY-7184pyrimidine deoxyribonucleotides de novo biosynthesis
humancycPWY-7211superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
kegghsa00240Pyrimidine metabolism - Homo sapiens (human)
kegghsa00983Drug metabolism - other enzymes - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DUT

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