DYNLL1
Summary: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dynein light chain LC8-type 1 | MIM:601562 | Ensembl:ENSG00000088986 | HGNC:HGNC:15476 | PA134972261 | 12q24.31 |
Gene Categories:
TUMOR SUPPRESSORGO terms in DYNLL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed |
| MF | IEA | GO:0019899 | enzyme binding |
| MF | IEA | GO:0030235 | nitric-oxide synthase regulator activity |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0045505 | dynein intermediate chain binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IBA | GO:0051959 | dynein light intermediate chain binding |
| MF | IEA | GO:0097110 | scaffold protein binding |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007286 | spermatid development |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0016236 | macroautophagy |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | HEP | GO:0021762 | substantia nigra development |
| BP | TAS | GO:0035735 | intraciliary transport involved in cilium assembly |
| BP | IEA | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | IDA | GO:0042326 | negative regulation of phosphorylation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0060271 | cilium assembly |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IBA | GO:2000582 | positive regulation of ATP-dependent microtubule motor activity, plus-end-directed |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005868 | cytoplasmic dynein complex |
| CC | IDA | GO:0005868 | cytoplasmic dynein complex |
| CC | ISS | GO:0005868 | cytoplasmic dynein complex |
| CC | IEA | GO:0005874 | microtubule |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005929 | cilium |
| CC | IDA | GO:0008180 | COP9 signalosome |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0030286 | dynein complex |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| CC | IDA | GO:0072686 | mitotic spindle |
| CC | TAS | GO:0097542 | ciliary tip |
| CC | TAS | GO:0101003 | ficolin-1-rich granule membrane |
| CC | IEA | GO:1904115 | axon cytoplasm |
Gene expression in normal tissue: DYNLL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DYNLL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04962 | Vasopressin-regulated water reabsorption - Homo sapiens (human) |
| biocarta | lis1pathway | lissencephaly gene (lis1) in neuronal migration and development |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111446 | Activation of BIM and translocation to mitochondria |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5620924 | Intraflagellar transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6807878 | COPI-mediated anterograde transport |
| reactome | R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DYNLL1
CLASSFICATION
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