DYNLL1


Summary: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
dynein light chain LC8-type 1MIM:601562Ensembl:ENSG00000088986HGNC:HGNC:15476PA13497226112q24.31

Gene Categories:

TUMOR SUPPRESSOR

GO terms in DYNLL1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0008574ATP-dependent microtubule motor activity, plus-end-directed
MFIEAGO:0019899enzyme binding
MFIEAGO:0030235nitric-oxide synthase regulator activity
MFIEAGO:0042803protein homodimerization activity
MFIBAGO:0045505dynein intermediate chain binding
MFIEAGO:0046982protein heterodimerization activity
MFIBAGO:0051959dynein light intermediate chain binding
MFIEAGO:0097110scaffold protein binding
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIEAGO:0006915apoptotic process
BPIEAGO:0007286spermatid development
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPIEAGO:0016032viral process
BPTASGO:0016236macroautophagy
BPTASGO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
BPHEPGO:0021762substantia nigra development
BPTASGO:0035735intraciliary transport involved in cilium assembly
BPIEAGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus
BPIDAGO:0042326negative regulation of phosphorylation
BPTASGO:0043312neutrophil degranulation
BPIBAGO:0060271cilium assembly
BPTASGO:0097711ciliary basal body-plasma membrane docking
BPIBAGO:2000582positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
CCIDAGO:0000776kinetochore
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCIDAGO:0005813centrosome
CCTASGO:0005829cytosol
CCIBAGO:0005868cytoplasmic dynein complex
CCIDAGO:0005868cytoplasmic dynein complex
CCISSGO:0005868cytoplasmic dynein complex
CCIEAGO:0005874microtubule
CCTASGO:0005886plasma membrane
CCTASGO:0005929cilium
CCIDAGO:0008180COP9 signalosome
CCHDAGO:0016020membrane
CCIBAGO:0030286dynein complex
CCTASGO:0070821tertiary granule membrane
CCIDAGO:0072686mitotic spindle
CCTASGO:0097542ciliary tip
CCTASGO:0101003ficolin-1-rich granule membrane
CCIEAGO:1904115axon cytoplasm

Gene expression in normal tissue: DYNLL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DYNLL1


DatabasePathway IDPathway Des.
netpathPathway_EGFR1EGFR1
kegghsa04962Vasopressin-regulated water reabsorption - Homo sapiens (human)
biocartalis1pathwaylissencephaly gene (lis1) in neuronal migration and development
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111446Activation of BIM and translocation to mitochondria
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-141424Amplification of signal from the kinetochores
reactomeR-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1632852Macroautophagy
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-2132295MHC class II antigen presentation
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2467813Separation of Sister Chromatids
reactomeR-HSA-2500257Resolution of Sister Chromatid Cohesion
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-3371497HSP90 chaperone cycle for steroid hormone receptors (SHR)
reactomeR-HSA-380259Loss of Nlp from mitotic centrosomes
reactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexes
reactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosome
reactomeR-HSA-380287Centrosome maturation
reactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomes
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620912Anchoring of the basal body to the plasma membrane
reactomeR-HSA-5620924Intraflagellar transport
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5663220RHO GTPases Activate Formins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-6807878COPI-mediated anterograde transport
reactomeR-HSA-6811436COPI-independent Golgi-to-ER retrograde traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68882Mitotic Anaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69618Mitotic Spindle Checkpoint
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-8854518AURKA Activation by TPX2
reactomeR-HSA-8856688Golgi-to-ER retrograde transport
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-948021Transport to the Golgi and subsequent modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DYNLL1

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