E4F1


Summary: The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
E4F transcription factor 1MIM:603022Ensembl:ENSG00000167967HGNC:HGNC:3121PA2757916p13.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in E4F1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFICGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFTASGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFTASGO:0003713transcription coactivator activity
MFTASGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIEAGO:0016740transferase activity
MFIDAGO:0035497cAMP response element binding
MFIEAGO:0046872metal ion binding
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIEAGO:0005819spindle
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006260DNA replication
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0008283cell proliferation
BPIEAGO:0009794regulation of mitotic cell cycle, embryonic
BPIDAGO:0010564regulation of cell cycle process
BPIEAGO:0016032viral process
BPIEAGO:0016567protein ubiquitination
BPIEAGO:0040008regulation of growth
BPIEAGO:0051301cell division
BPTASGO:0071850mitotic cell cycle arrest
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription

Gene expression in normal tissue: E4F1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in E4F1


DatabasePathway IDPathway Des.
pidp53regulationpathwayp53 pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in E4F1

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