ECSCR
Summary: The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| endothelial cell surface expressed chemotaxis and apoptosis regulator | MIM:615736 | Ensembl:ENSG00000249751 | HGNC:HGNC:35454 | PA164718891 | 5q31.2 |
GO terms in ECSCR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006935 | chemotaxis |
| BP | IBA | GO:0016525 | negative regulation of angiogenesis |
| BP | IMP | GO:0016525 | negative regulation of angiogenesis |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IBA | GO:1901800 | positive regulation of proteasomal protein catabolic process |
| BP | IMP | GO:1901800 | positive regulation of proteasomal protein catabolic process |
| BP | IBA | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| BP | IMP | GO:2000353 | positive regulation of endothelial cell apoptotic process |
Gene expression in normal tissue: ECSCR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ECSCR
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ECSCR
CLASSFICATION
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