ECSCR


Summary: The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
endothelial cell surface expressed chemotaxis and apoptosis regulatorMIM:615736Ensembl:ENSG00000249751HGNC:HGNC:35454PA1647188915q31.2

GO terms in ECSCR


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0043231intracellular membrane-bounded organelle
BPIEAGO:0001525angiogenesis
BPIEAGO:0006915apoptotic process
BPIEAGO:0006935chemotaxis
BPIBAGO:0016525negative regulation of angiogenesis
BPIMPGO:0016525negative regulation of angiogenesis
BPIEAGO:0030154cell differentiation
BPIBAGO:1901800positive regulation of proteasomal protein catabolic process
BPIMPGO:1901800positive regulation of proteasomal protein catabolic process
BPIBAGO:2000353positive regulation of endothelial cell apoptotic process
BPIMPGO:2000353positive regulation of endothelial cell apoptotic process

Gene expression in normal tissue: ECSCR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ECSCR


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD812Antiangiogenic Therapy1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ECSCR

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