EFNB3
Summary: EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ephrin B3 | MIM:602297 | Ensembl:ENSG00000108947 | HGNC:HGNC:3228 | PA27663 | 17p13.1 |
GO terms in EFNB3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | TAS | GO:0007267 | cell-cell signaling |
BP | TAS | GO:0007399 | nervous system development |
BP | IBA | GO:0007411 | axon guidance |
BP | IEA | GO:0007628 | adult walking behavior |
BP | IEA | GO:0016198 | axon choice point recognition |
BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
BP | IEA | GO:0031295 | T cell costimulation |
BP | IEA | GO:0046718 | viral entry into host cell |
BP | IBA | GO:0048013 | ephrin receptor signaling pathway |
BP | IDA | GO:0048013 | ephrin receptor signaling pathway |
BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
BP | ISS | GO:0050771 | negative regulation of axonogenesis |
CC | IBA | GO:0005886 | plasma membrane |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | TAS | GO:0005887 | integral component of plasma membrane |
MF | IEA | GO:0001618 | virus receptor activity |
MF | EXP | GO:0004713 | protein tyrosine kinase activity |
MF | TAS | GO:0005005 | transmembrane-ephrin receptor activity |
MF | IBA | GO:0046875 | ephrin receptor binding |
MF | IDA | GO:0046875 | ephrin receptor binding |
Gene expression in normal tissue: EFNB3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EFNB3
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-2682334 | EPH-Ephrin signaling |
reactome | R-HSA-2682334 | EPH-Ephrin signaling |
reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
reactome | R-HSA-3928664 | Ephrin signaling |
reactome | R-HSA-3928664 | Ephrin signaling |
reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
reactome | R-HSA-422475 | Axon guidance |
reactome | R-HSA-422475 | Axon guidance |
pid | ephbfwdpathway | EPHB forward signaling |
kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EFNB3