Summary: EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008].

ephrin B3MIM:602297Ensembl:ENSG00000108947HGNC:HGNC:3228PA2766317p13.1

GO terms in EFNB3

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007267cell-cell signaling
BPTASGO:0007399nervous system development
BPIBAGO:0007411axon guidance
BPIEAGO:0007628adult walking behavior
BPIEAGO:0016198axon choice point recognition
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0031295T cell costimulation
BPIEAGO:0046718viral entry into host cell
BPIBAGO:0048013ephrin receptor signaling pathway
BPIDAGO:0048013ephrin receptor signaling pathway
BPTASGO:0048013ephrin receptor signaling pathway
BPISSGO:0050771negative regulation of axonogenesis
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
MFIEAGO:0001618virus receptor activity
MFEXPGO:0004713protein tyrosine kinase activity
MFTASGO:0005005transmembrane-ephrin receptor activity
MFIBAGO:0046875ephrin receptor binding
MFIDAGO:0046875ephrin receptor binding

Gene expression in normal tissue: EFNB3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EFNB3

DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928664Ephrin signaling
reactomeR-HSA-3928664Ephrin signaling
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
pidephbfwdpathwayEPHB forward signaling
kegghsa04360Axon guidance - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EFNB3