Summary: This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

engulfment and cell motility 1MIM:606420Ensembl:ENSG00000155849HGNC:HGNC:16286PA277547p14.2-p14.1

GO terms in ELMO1

Term TypeEvidence TypeGO Term IDGO Des.
BPIGIGO:0006911phagocytosis, engulfment
BPNASGO:0006915apoptotic process
BPIEAGO:0016477cell migration
BPIGIGO:0016601Rac protein signal transduction
BPIGIGO:0030036actin cytoskeleton organization
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIGIGO:0048870cell motility
BPTASGO:0050690regulation of defense response to virus by virus
CCIDAGO:0005886plasma membrane
CCIDAGO:0032045guanyl-nucleotide exchange factor complex
MFIDAGO:0005085guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0017124SH3 domain binding

Gene expression in normal tissue: ELMO1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ELMO1

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-164944Nef and signal transduction
reactomeR-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesis
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP3929Chemokine signaling pathway
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidnetrin_pathwayNetrin-mediated signaling events
pidrac1_reg_pathwayRegulation of RAC1 activity
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ELMO1