ELMO1
Summary: This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| engulfment and cell motility 1 | MIM:606420 | Ensembl:ENSG00000155849 | HGNC:HGNC:16286 | PA27754 | 7p14.2-p14.1 |
GO terms in ELMO1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IGI | GO:0006911 | phagocytosis, engulfment |
| BP | NAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0016477 | cell migration |
| BP | IGI | GO:0016601 | Rac protein signal transduction |
| BP | IGI | GO:0030036 | actin cytoskeleton organization |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IGI | GO:0048870 | cell motility |
| BP | TAS | GO:0050690 | regulation of defense response to virus by virus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0032045 | guanyl-nucleotide exchange factor complex |
| MF | IDA | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0017124 | SH3 domain binding |
Gene expression in normal tissue: ELMO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ELMO1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-164944 | Nef and signal transduction |
| reactome | R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849471 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP3929 | Chemokine signaling pathway |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| netpath | Pathway_TCR | TCR |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ELMO1
CLASSFICATION
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