EPCAM
Summary: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| epithelial cell adhesion molecule | MIM:185535 | Ensembl:ENSG00000119888 | HGNC:HGNC:11529 | PA35493 | 2p21 |
GO terms in EPCAM
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | IBA | GO:0098641 | cadherin binding involved in cell-cell adhesion |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005923 | bicellular tight junction |
| CC | IDA | GO:0005923 | bicellular tight junction |
| CC | IEA | GO:0009986 | cell surface |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0016328 | lateral plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001657 | ureteric bud development |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0023019 | signal transduction involved in regulation of gene expression |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0048863 | stem cell differentiation |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| BP | IDA | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin |
| BP | IMP | GO:2000648 | positive regulation of stem cell proliferation |
Gene expression in normal tissue: EPCAM
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPCAM
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPCAM
CLASSFICATION
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